tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate
CAS No.:1393901-28-4
Molecular Formula:C₃₀H₃₃F₃N₆O₃
Molecular Weight:582.626
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

There total 12 articles about tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1393901-26-2
tert-butyl 4-(4-((4-((3-oxoisoindolin-4-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

: 1393901-28-4
tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: With hydrogen; 10 wt% Pd(OH)2 on carbon; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1393901-28-4
tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-iodo-succinimide / palladium diacetate / N,N-dimethyl-formamide / 17 h / 100 °C

2.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.75 h / 0 °C / Inert atmosphere

3.1: N-Bromosuccinimide / dibenzoyl peroxide / chlorobenzene / 18 h / 90 °C

3.2: 17 h

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.67 h / 100 °C / microwave irradiation

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

6.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

7.1: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; diazomethyl-trimethyl-silane; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; 10 wt% Pd(OH)2 on carbon; palladium diacetate; triphenylphosphine; dibenzoyl peroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1393901-28-4
tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With hydrogen; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;