4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

Base Information

Chemical Name:4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide
CAS No.:101535-79-9
Molecular Formula:C₂₂H₂₃N₅O₄S
Molecular Weight:453.522
Hs Code.:

Synonyms:4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

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Chemical Property of 4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

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Technology Process of 4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

There total 8 articles about 4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 101535-71-1
4-amino-3-(2-benzyloxyethoxy)methylpyrazole-5-carboxamide

: 532-55-8
Benzoyl isothiocyanate

: 101535-79-9
4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

Reference yield:

: 5334-38-3
3-methyl-4-nitropyrazole-5-carboxylic acid

: 101535-79-9
4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / conc. H₂SO₄ / 3 h / Heating

2: 72 percent / fuming HNO₃, Ac₂O / acetic acid / 1 h / Ambient temperature

3: 63 percent / triethylamine / CH₂Cl₂ / 0.17 h / 6 °C

4: DMF, thionylchloride / 4 h / Heating

5: 2,6-dimethylpyridine, silver tetrafluoroborate / acetonitrile / 50 °C

6: 27 g / conc. NH₃ / dioxane / 8 h / 110 °C

7: 61 percent / KHCO₃, sodium dithionite / ethanol; ethyl acetate; H₂O / 1 h

8: 90 percent / dimethylformamide / 1.5 h / Ambient temperature

With 2,6-dimethylpyridine; ammonium hydroxide; silver tetrafluoroborate; thionyl chloride; sodium dithionite; sulfuric acid; nitric acid; acetic anhydride; potassium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 101535-68-6
isopropyl 3-chloromethyl-4-nitropyrazole-5-carboxylate

: 101535-79-9
4-(N'-benzoylthioureido)amino-3-(2-benzyloxyethoxymethyl)pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine, silver tetrafluoroborate / acetonitrile / 50 °C

2: 27 g / conc. NH₃ / dioxane / 8 h / 110 °C

3: 61 percent / KHCO₃, sodium dithionite / ethanol; ethyl acetate; H₂O / 1 h

4: 90 percent / dimethylformamide / 1.5 h / Ambient temperature

With 2,6-dimethylpyridine; ammonium hydroxide; silver tetrafluoroborate; sodium dithionite; potassium hydrogencarbonate; In 1,4-dioxane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;