N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

Base Information

Chemical Name:N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine
CAS No.:1345693-51-7
Molecular Formula:C₃₀H₃₈ClNO₂Si
Molecular Weight:508.176
Hs Code.:

Synonyms:N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

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Technology Process of N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

There total 3 articles about N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-(4-chlorophenyl)-2-(dibenzylamino)acetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

: 1345693-51-7
N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 18h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo201692x

Reference yield:

: 5445-25-0
ethyl 2-bromo-2-(4-chlorophenyl)acetate

: N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

: 1345693-51-7
N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 19 h / Inert atmosphere; Reflux

2: potassium hexamethylsilazane / tetrahydrofuran; toluene / 18 h / -78 - 20 °C / Inert atmosphere

With potassium hexamethylsilazane; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo201692x

Reference yield:

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

: N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

: 1345693-51-7
N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-2-ethoxy-1-(4-chlorophenyl)ethenamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2.5 h / Inert atmosphere; Reflux

2: ethanol / 19 h / Inert atmosphere; Reflux

3: potassium hexamethylsilazane / tetrahydrofuran; toluene / 18 h / -78 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium hexamethylsilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; toluene;
DOI:10.1021/jo201692x