(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

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Chemical Name:(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid
CAS No.:1307950-50-0
Molecular Formula:C₂₉H₂₆F₃N₃O₅
Molecular Weight:553.538
Hs Code.:

Synonyms:(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

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Chemical Property of (3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

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Technology Process of (3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

There total 10 articles about (3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307812-62-9
7-(oxiran-2-yl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1307950-50-0
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: With lithium perchlorate; In 1-methyl-pyrrolidin-2-one; at 20 - 100 ℃; for 71.5h; Sealed vial;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307950-50-0
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

5.2: 1.17 h / 0 °C

5.3: 3 h / 110 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

7.1: lithium perchlorate / 1-methyl-pyrrolidin-2-one / 71.5 h / 20 - 100 °C / Sealed vial

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; n-butyllithium; lithium hydroxide monohydrate; lithium perchlorate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 536-74-3
phenylacetylene

: 1307950-50-0
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

6.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

6.2: 1.17 h / 0 °C

6.3: 3 h / 110 °C / Inert atmosphere

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

8.1: lithium perchlorate / 1-methyl-pyrrolidin-2-one / 71.5 h / 20 - 100 °C / Sealed vial

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; n-butyllithium; lithium hydroxide monohydrate; lithium perchlorate; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;