4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester

Base Information

Chemical Name:4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester
CAS No.:131747-73-4
Molecular Formula:C₁₇H₁₈BrClN₂O₄
Molecular Weight:429.698
Hs Code.:

Synonyms:4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester

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Chemical Property of 4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester

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Technology Process of 4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester

There total 1 articles about 4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 131747-73-4
4-Bromo-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-(2-chloro-ethyl) ester 3'-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / PCl₃ / CHCl₃ / 3 h / Ambient temperature

2: 61 percent / AcBr / 6 h / Heating

3: KMnO₄ / H₂O / Heating

4: 1) NEt₃, ethyl chloroformate, 2) LiAlH₄ / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min

5: 69 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

6: propan-2-ol / 40 °C

With potassium permanganate; lithium aluminium tetrahydride; Acetyl bromide; phosphoric acid; chloroformic acid ethyl ester; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; phosphorus trichloride; In chloroform; water; isopropyl alcohol;
DOI:10.1248/cpb.38.2446