(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

Base Information

Chemical Name:(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one
CAS No.:1312954-65-6
Molecular Formula:C₁₆H₁₉ClFN₅O
Molecular Weight:351.811
Hs Code.:

Synonyms:(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

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Chemical Property of (R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

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Technology Process of (R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

There total 9 articles about (R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312954-64-5
(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

: 1312954-65-6
(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

Guidance literature:: (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 81778-09-8
1-(bromomethyl)-2-chloro-5-fluorobenzene

: 1312954-65-6
(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

3: sulfuric acid / methanol / 15 h / Reflux

4: sodium methylate / methanol / 36 h / Reflux

5: sodium hydroxide / ethanol / 0.67 h / 20 °C

6: 14 h / 130 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With hydrazine hydrate; sodium methylate; trifluoroacetic acid; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 647020-63-1
methyl 2-chloro-5-fluorobenzoate

: 1312954-65-6
(R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one

Guidance literature:: Multi-step reaction with 9 steps

1: sodium tetrahydroborate; methanol / 1 h / 20 °C

2: phosphorus tribromide / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

3: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

4: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

5: sulfuric acid / methanol / 15 h / Reflux

6: sodium methylate / methanol / 36 h / Reflux

7: sodium hydroxide / ethanol / 0.67 h / 20 °C

8: 14 h / 130 °C / Inert atmosphere

9: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With methanol; sodium tetrahydroborate; hydrazine hydrate; sodium methylate; phosphorus tribromide; trifluoroacetic acid; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;