(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate
CAS No.:1312954-64-5
Molecular Formula:C₂₁H₂₇ClFN₅O₃
Molecular Weight:451.928
Hs Code.:

Synonyms:(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

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Chemical Property of (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

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Technology Process of (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

There total 9 articles about (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1312954-63-4
4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

: 1312954-64-5
(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

Guidance literature:: at 130 ℃; for 14h; Inert atmosphere;

Reference yield:

: 2252-50-8
2-chloro-5-fluoro-benzoic acid

: 1312954-64-5
(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / 24 h / Reflux

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: phosphorus tribromide / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

4: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

5: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

6: sulfuric acid / methanol / 15 h / Reflux

7: sodium methylate / methanol / 36 h / Reflux

8: sodium hydroxide / ethanol / 0.67 h / 20 °C

9: 14 h / 130 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; hydrazine hydrate; sulfuric acid; sodium methylate; phosphorus tribromide; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 81778-09-8
1-(bromomethyl)-2-chloro-5-fluorobenzene

: 1312954-64-5
(R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

3: sulfuric acid / methanol / 15 h / Reflux

4: sodium methylate / methanol / 36 h / Reflux

5: sodium hydroxide / ethanol / 0.67 h / 20 °C

6: 14 h / 130 °C / Inert atmosphere

With hydrazine hydrate; sodium methylate; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;