5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

Base Information

Chemical Name:5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride
CAS No.:1420199-34-3
Molecular Formula:C₂₄H₂₃N₇*ClH
Molecular Weight:445.954
Hs Code.:

Synonyms:5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

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Chemical Property of 5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

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Technology Process of 5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

There total 6 articles about 5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1420205-31-7
C₁₄H₂₀ClNO*ClH

: 1420205-64-6
C₁₂H₁₂N₆O

: 1420199-34-3
5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

Guidance literature:: C₁₄H₂₀ClNO*ClH; C₁₂H₁₂N₆O; With 1H-imidazole; In methanol; at 0 - 60 ℃; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol;

Reference yield:

: 1420205-57-7
C₁₀H₁₀N₄O₂

: 1420199-34-3
5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium ethoxide / ethanol / 0.5 h / Cooling with ice; Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / 20 °C / Reflux

3.1: hydrazine hydrate / ethanol / Reflux

4.1: 1H-imidazole / methanol / 0 - 60 °C / Inert atmosphere

With 1H-imidazole; potassium ethoxide; iron; ammonium chloride; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 22280-60-0
6-chloro-4-methyl-3-nitropyridine

: 1420199-34-3
5,6,7,8-tetrahydro-2-[5-(4-methyl-1H-imidazol-1-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-8-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 16 h / 100 °C

2.1: potassium ethoxide / ethanol / 0.5 h / Cooling with ice; Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / 20 °C / Reflux

4.1: hydrazine hydrate / ethanol / Reflux

5.1: 1H-imidazole / methanol / 0 - 60 °C / Inert atmosphere

With 1H-imidazole; potassium ethoxide; iron; ammonium chloride; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;