1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea

Base Information

• Chemical Name: 1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea
• CAS No.: 1268450-71-0
• Molecular Formula: C₁₅H₁₁F₆N₃O
• Molecular Weight: 363.262
• Mol file: 1268450-71-0.mol

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea

Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea

There total 1 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) + 3,5-ditrifluoromethylisocyanate (16588-74-2) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea (1268450-71-0)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.jorganchem.2010.09.075

Reference yield: 94.0%

1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyridin-2-ylmethyl)urea (1268450-71-0) + palladium diacetate (3375-31-3) → [Pd(1-(3,5-bis(trifluorophenyl)-3-(pyridin-2-ylmethyl)urea(-H))2] (1268450-74-3)

Guidance literature:

With LiOH*H₂O; In methanol; ligand, LiOH*H2O, and Pd compd. (2.2:3:1 molar ratio) in MeOH, stirred at room temp. for 24 h; evapd., washed (H2O, ethyl acetate), dried (vac.), elem. anal.;

DOI:10.1016/j.jorganchem.2010.09.075

upstream raw materials:

2-(Aminomethyl)pyridine

3,5-ditrifluoromethylisocyanate

Downstream raw materials:

[Pd(1-(3,5-bis(trifluorophenyl)-3-(pyridin-2-ylmethyl)urea(-H))2]