Technology Process of 1-(4-chlorobenzyl)-1H-benzo[d]imidazole-5-carboxylic acid
There total 5 articles about 1-(4-chlorobenzyl)-1H-benzo[d]imidazole-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 1-(4-chlorobenzyl)-1H-benzo[d]imidazole-5-carboxylate;
With
sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=6;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 50 °C
2.1: pyridinium p-toluenesulfonate; palladium on activated charcoal; hydrogen / ethyl acetate / 8 h / 20 °C / 2585.81 Torr
3.1: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C
3.2: pH 6
With
palladium on activated charcoal; hydrogen; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / Reflux
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 50 °C
3.1: pyridinium p-toluenesulfonate; palladium on activated charcoal; hydrogen / ethyl acetate / 8 h / 20 °C / 2585.81 Torr
4.1: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C
4.2: pH 6
With
thionyl chloride; palladium on activated charcoal; hydrogen; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; ethyl acetate;