[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone

Base Information

Chemical Name:[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone
CAS No.:344457-87-0
Molecular Formula:C₂₁H₁₇ClFNO
Molecular Weight:353.823
Hs Code.:
UNII:WX9Y9W9AAY
Pharos Ligand ID:PTLJ11JQBS53
ChEMBL ID:CHEMBL152208

Synonyms:EO-1606;WX9Y9W9AAY;344457-87-0;UNII-WX9Y9W9AAY;EO1606;CHEMBL152208;(2-Chloro-4-(4-fluoro-2-methyl-anilino)phenyl)-(o-tolyl)methanone;[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone;(2-Chloro-4-((4-fluoro-2-methylphenyl)amino)phenyl)(2-methylphenyl)methanone;Methanone, (2-chloro-4-((4-fluoro-2-methylphenyl)amino)phenyl)(2-methylphenyl)-;(2-chloro-4-((4-fluoro-2-methylphenyl)amino)phenyl)(o-tolyl)methanone;SCHEMBL1906200;QIBLVZMAUUVSMB-UHFFFAOYSA-N;BDBM50136890;AKOS040751694;PD160999;2-chloro-4-(4-fluoro-2-methyl-phenylamino)-2'-methylbenzophenone;[2-chloro-4-(4-fluoro-2-methylanilino)phenyl]-(2-methylphenyl)methanone

Suppliers and Price of [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone

Chemical Property:

XLogP3:6.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:353.0982700
Heavy Atom Count:25
Complexity:459

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=CC=C1C(=O)C2=C(C=C(C=C2)NC3=C(C=C(C=C3)F)C)Cl

Technology Process of [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone

There total 8 articles about [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 452-71-1
4-fluor-2-methylaniline

: 740815-24-1
(4-bromo-2-chlorophenyl)(2-methylphenyl)methanone

: 344457-87-0
{2-chloro-4-[(4-fluoro-2-methylphenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: With Celite; caesium carbonate; XPhos; palladium diacetate; In toluene; tert-butyl alcohol; at 150 ℃; for 0.333333h; microwave irradiation;
DOI:10.1021/jo049572i

Reference yield:

: 31928-47-9
4-bromo-2-chloroiodobenzene

: 344457-87-0
{2-chloro-4-[(4-fluoro-2-methylphenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -60 °C

1.2: 92 percent / tetrahydrofuran / -60 - 20 °C

2.1: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 79 percent / Cs₂CO₃; dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphane; Celite / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 0.33 h / 150 °C / microwave irradiation

With Celite; isopropylmagnesium chloride; caesium carbonate; Dess-Martin periodane; XPhos; palladium diacetate; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/jo049572i

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 344457-87-0
{2-chloro-4-[(4-fluoro-2-methylphenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -60 °C

1.2: 92 percent / tetrahydrofuran / -60 - 20 °C

2.1: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 79 percent / Cs₂CO₃; dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphane; Celite / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 0.33 h / 150 °C / microwave irradiation

With Celite; isopropylmagnesium chloride; caesium carbonate; Dess-Martin periodane; XPhos; palladium diacetate; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/jo049572i