(5Z)-1-(3-chlorophenyl)-5-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Base Information

• Chemical Name: (5Z)-1-(3-chlorophenyl)-5-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• CAS No.: 5810-64-0
• Molecular Formula: C14H14 N2 O3
• Molecular Weight: 258.277

Synonyms:5-Pyrimidineaceticacid, 1,4-dihydro-4-oxo-2-phenyl-, ethyl ester (9CI); 5-Pyrimidineacetic acid,4-hydroxy-2-phenyl-, ethyl ester (7CI,8CI)

Chemical Property of (5Z)-1-(3-chlorophenyl)-5-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.54g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5Z)-1-(3-chlorophenyl)-5-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

There total 3 articles about (5Z)-1-(3-chlorophenyl)-5-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzamidin (618-39-3) + diethyl 2-formylbutanedioate (5472-38-8) → ethyl 2-(4-hydroxy-2-phenylpyrimidin-5-yl)acetate (5810-64-0)

Guidance literature:

diethyl 2-formylbutanedioate; With sodium ethanolate; In ethanol; at 0 ℃; for 0.0833333h; Inert atmosphere;

benzamidin; In ethanol; at 0 - 20 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1007/s00706-015-1634-1

Reference yield:

→ (6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester (5810-64-0)

Guidance literature:

Entspr. Amidin, Formylsuccinat;

Reference yield:

→ ethyl 2-(4-hydroxy-2-phenylpyrimidin-5-yl)acetate (5810-64-0)

Guidance literature:

Bernsteinsaeure-diethylester + Ameisensaeure-ethylester + Na in Bzl., dann + Benz-amidin in A.;

upstream raw materials:

benzamidin

diethyl 2-formylbutanedioate

Downstream raw materials:

2-(4-amino-2-phenylpyrimidin-5-yl)acetamide

ethyl 2-(4-chloro-2-phenylpyrimidin-5-yl)acetate

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