C₄₂H₅₇NO₁₄

Base Information

• Chemical Name: C₄₂H₅₇NO₁₄
• CAS No.: 1243575-79-2
• Molecular Formula: C₄₂H₅₇NO₁₄
• Molecular Weight: 799.913
• Mol file: 1243575-79-2.mol

Synonyms:C₄₂H₅₇NO₁₄

Chemical Property of C₄₂H₅₇NO₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₅₇NO₁₄

There total 4 articles about C₄₂H₅₇NO₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.1%

desisobutyryl ciclesonide (161115-59-9) + 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl fluoride (439-02-1,60894-74-8,89064-87-9) → C42H57NO14 (1243575-79-2) + C42H57NO14 (1243575-80-5)

Guidance literature:

desisobutyryl ciclesonide; 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl fluoride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere; Molecular sieve;

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; Cooling with ice-salt bath;

Reference yield:

ciclesonide (126544-47-6,141845-82-1) → C42H57NO14 (1243575-79-2) + C42H57NO14 (1243575-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h

2.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 20 °C / Cooling with ice-salt bath

With water; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

N-Acetyl-D-glucosamine (7512-17-6,72-87-7,1136-42-1,1136-44-3,6082-29-7,6730-06-9,7772-94-3,10036-64-3,14131-60-3,14131-64-7,14131-68-1,14215-68-0,62057-49-2,62057-50-5,62057-51-6,62057-52-7,62057-53-8,62057-54-9,62057-55-0,62057-56-1,62075-50-7,62137-54-6,134451-97-1,134522-12-6,148347-16-4) → C42H57NO14 (1243575-79-2) + C42H57NO14 (1243575-80-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 16 h / 20 °C

2.1: pyridine; hydrogen fluoride / dichloromethane / 24 h / 20 °C / Cooling with ice

3.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: 20 °C / Cooling with ice-salt bath

With pyridine; hydrogen fluoride; In dichloromethane;

upstream raw materials:

ciclesonide

N-Acetyl-D-glucosamine

desisobutyryl ciclesonide

2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl fluoride

Refernces

• 1、 -. "STEROID COMPOUND". . . Retrieved 2012/02/04.