(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

Base Information

Chemical Name:(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol
CAS No.:179945-00-7
Molecular Formula:C₄₁H₄₆O₃Si
Molecular Weight:614.9
Hs Code.:

Synonyms:(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

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Technology Process of (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

There total 3 articles about (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 179944-99-1
(2S,4R)-2-Methyl-5-trityloxy-pentane-1,4-diol

: 179945-00-7
(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/chem.201303713

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 179944-99-1
(2S,4R)-2-Methyl-5-trityloxy-pentane-1,4-diol

: 93547-88-7
t-butyl diphenylsilanol

: 179945-00-7
(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 1.7h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo9606113

Reference yield:

: 180062-86-6
2(S)-methyl-(R)-(-)-γ-trityloxymethyl-γ-butyrolactone

: 179945-00-7
(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-1-trityloxy-pentan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.201303713