3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

Base Information

Chemical Name:3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid
CAS No.:1143502-60-6
Molecular Formula:C₂₆H₃₁F₃N₄O₄
Molecular Weight:520.552
Hs Code.:

Synonyms:3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

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Chemical Property of 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

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Technology Process of 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

There total 1 articles about 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1143502-59-3
phenylmethyl 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoate

: 1143502-60-6
3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h; under 37503.8 Torr;

Reference yield:

: 1143502-60-6
3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

: 17704-74-4
2-Amino-2-methyl-propionamide hydrochloride

: 1143502-63-9
N-(2-amino-1,1-dimethyl-2-oxoethyl)-3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzamide

Guidance literature:: 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-Amino-2-methyl-propionamide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1143502-60-6
3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid

: 1668-10-6
glycinamide hydrochloride

: 1143502-65-1
C₂₈H₃₅F₃N₆O₄

: 1143502-64-0
C₂₈H₃₅F₃N₆O₄

Guidance literature:: 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(2-methylpropanoyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

glycinamide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;