4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide

Base Information

• Chemical Name: 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide
• CAS No.: 1301630-40-9
• Molecular Formula: C₂₈H₃₈N₄O₄
• Molecular Weight: 494.634

Synonyms:4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide

Chemical Property of 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide

Chemical Property:

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Technology Process of 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide

There total 3 articles about 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyl 6-(4-(5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-3-(ethylcarbamoyl)isoxazol-4-yl)benzylamino)hexylcarbamate (1301630-39-6) → 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide (1301630-40-9)

Guidance literature:

With boron trichloride; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/j.bmc.2011.03.013

Reference yield:

1,6-Hexanediamine (124-09-4) → 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide (1301630-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C / Molecular sieve

3: boron trichloride / dichloromethane / 10 h / 20 °C

With boron trichloride; sodium cyanoborohydride; acetic acid; triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2011.03.013

Reference yield:

tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) → 4-(4-((6-aminohexylamino)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide (1301630-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C / Molecular sieve

2: boron trichloride / dichloromethane / 10 h / 20 °C

With boron trichloride; sodium cyanoborohydride; acetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2011.03.013

upstream raw materials:

1,6-Hexanediamine

tert-butyl 6-(4-(5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-3-(ethylcarbamoyl)isoxazol-4-yl)benzylamino)hexylcarbamate

tert-butyl N-(6-aminohexyl)carbamate

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