Technology Process of C16H17NO
There total 2 articles about C16H17NO which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tri(4-tolyl)boroxine;
With
diethylzinc;
In
toluene;
at 60 ℃;
for 12h;
Inert atmosphere;
3,4-dihydro-isoquinoline 2-oxide;
With
diethylzinc; [(1S)-1-((S)-1-methylpropyl)-(2-morpholin-4-ylethyl)]carbamic acid tert-butyl ester;
In
dichloromethane; toluene;
at -30 - -20 ℃;
for 24.25h;
Inert atmosphere;
With
methanol;
In
dichloromethane; toluene;
at -20 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol1004356
- Guidance literature:
-
p-tolylboronic pinacol ester;
With
diethylzinc;
In
toluene;
at 70 ℃;
for 12h;
Inert atmosphere;
3,4-dihydro-isoquinoline 2-oxide;
With
diethylzinc; [(1S)-1-((S)-1-methylpropyl)-(2-morpholin-4-ylethyl)]carbamic acid tert-butyl ester;
In
dichloromethane; toluene;
at -30 - -20 ℃;
for 24.25h;
Inert atmosphere;
With
methanol;
In
dichloromethane; toluene;
at -20 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol1004356