2-Bromo-3-iodoanisole

Base Information

• Chemical Name: 2-Bromo-3-iodoanisole
• CAS No.: 74128-84-0
• Molecular Formula: C7H6 Br I O
• Molecular Weight: 312.933
• Hs Code.: 2909309090
• Mol file: 74128-84-0.mol

Synonyms:2-Bromo-3-iodoanisole

Chemical Property of 2-Bromo-3-iodoanisole

Chemical Property:

• Melting Point: 46-47 °C(Solv: ethanol (64-17-5))
• Boiling Point: 298.2±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 2.062±0.06 g/cm3(Predicted)
• LogP: 3.06230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-1-iodo-3-methoxybenzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-iodoanisole

There total 10 articles about 2-Bromo-3-iodoanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-3-iodophenol (863870-88-6) + methyl iodide (74-88-4) → 2-bromo-1-iodo-3-methoxybenzene (74128-84-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b917839b

Reference yield: 68.0%

2-bromo-3-methoxyaniline (112970-44-2) → 2-bromo-1-iodo-3-methoxybenzene (74128-84-0)

Guidance literature:

2-bromo-3-methoxyaniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.333333h;

With potassium iodide; In water; at 20 ℃; for 12h;

Reference yield:

N-(3-methoxyphenyl)pivalamide (56619-93-3) → 2-bromo-1-iodo-3-methoxybenzene (74128-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 12 h / 0 °C

1.2: 90 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C

2.1: aq. HCl / dioxane / 3 h / Heating

3.1: aq. HCl; NaNO₂; KI / 0 °C

3.2: 24.7 g / aq. KI / 2 h / 80 °C

With hydrogenchloride; n-butyllithium; potassium iodide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; hexane;

DOI:10.1021/ja030552s

upstream raw materials:

2-bromo-3-methoxyaniline

N-(3-methoxyphenyl)pivalamide

m-Anisidine

N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide

Downstream raw materials:

2,7-diphenyl-1,8-dimethoxybiphenylene

2,7-dicyclohexyl-1,8-dimethoxybiphenylene

2,7-bis(3,5-di-tert-butylphenyl)-1,8-dimethoxybiphenylene

2,7-bis(3,5-di-tert-butylphenyl)-1,8-biphenylenediol