Technology Process of Acetic acid (2E,6E)-(1R,4R,5S,11R)-1-[(E)-(1R,2R)-1-(4-methoxy-benzyloxy)-2-methyl-hept-3-enyl]-4,11-dimethyl-10-methylene-13-(tetrahydro-pyran-2-yloxy)-5-(2-trimethylsilanyl-ethoxymethoxy)-trideca-2,6-dienyl ester
There total 14 articles about Acetic acid (2E,6E)-(1R,4R,5S,11R)-1-[(E)-(1R,2R)-1-(4-methoxy-benzyloxy)-2-methyl-hept-3-enyl]-4,11-dimethyl-10-methylene-13-(tetrahydro-pyran-2-yloxy)-5-(2-trimethylsilanyl-ethoxymethoxy)-trideca-2,6-dienyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: iPr2NEt, DMAP / CH2Cl2
2: 1.) Cp2ZrHCl, 2.) NIS / 1.) CH2Cl2, 2.) CH2Cl2
3: 84 percent / (PPh3)4Pd / 22 °C
4: TBAF / tetrahydrofuran
5: Dess-Martin periodinane, NaHCO3 / CH2Cl2
6: CrCl2 / tetrahydrofuran / Ambient temperature
7: 1.) t-BuLi, 2.) Me2Zn
8: 94 percent / pyridine, DMAP
With
pyridine; chromium dichloride; dmap; N-iodo-succinimide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; dimethyl zinc(II); tert.-butyl lithium; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja982572d
- Guidance literature:
-
Multi-step reaction with 10 steps
1: NCS, Ph3P / CH2Cl2 / Heating
2: LDA / tetrahydrofuran / -30 °C
3: iPr2NEt, DMAP / CH2Cl2
4: 1.) Cp2ZrHCl, 2.) NIS / 1.) CH2Cl2, 2.) CH2Cl2
5: 84 percent / (PPh3)4Pd / 22 °C
6: TBAF / tetrahydrofuran
7: Dess-Martin periodinane, NaHCO3 / CH2Cl2
8: CrCl2 / tetrahydrofuran / Ambient temperature
9: 1.) t-BuLi, 2.) Me2Zn
10: 94 percent / pyridine, DMAP
With
pyridine; chromium dichloride; dmap; N-chloro-succinimide; N-iodo-succinimide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; dimethyl zinc(II); tert.-butyl lithium; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja982572d
- Guidance literature:
-
Multi-step reaction with 6 steps
1: CrCl2 / tetrahydrofuran
2: (PPh3)4Pd / Ambient temperature
3: MeLi / diethyl ether
4: 1.) (COCl)2, DMSO, 2.) Et3N
5: 1.) t-BuLi, 2.) Me2Zn
6: 94 percent / pyridine, DMAP
With
pyridine; chromium dichloride; dmap; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; methyllithium; dimethyl zinc(II); tert.-butyl lithium; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/ja982572d
