Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate

Base Information

• Chemical Name: Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate
• CAS No.: 130024-09-8
• Molecular Formula: C₁₅H₁₄Cl₂N₄O₂
• Molecular Weight: 353.208
• Mol file: 130024-09-8.mol

Synonyms:Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate

Chemical Property of Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate

There total 2 articles about Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine (130024-06-5) + ethyl bromoacetate (105-36-2) → Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate (130024-09-8)

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1002/jhet.5570270401

Reference yield:

4,6-dichloro-1-p-chlorophenylpyrazolo<3,4-d>pyrimidine (5334-34-9) → Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate (130024-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaBH₄ / ethanol; CHCl₃ / Ambient temperature

2: 80 percent / 10N aq. NaOH, Bu₄NI / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; In ethanol; dichloromethane; chloroform;

DOI:10.1002/jhet.5570270401

Reference yield: 76.5%

Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate (130024-09-8) + N-butylamine (109-73-9,85404-21-3) → 8-Butyl-1-(4-chlorophenyl)-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one (132171-67-6)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Heating;

upstream raw materials:

6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine

ethyl bromoacetate

4,6-dichloro-1-p-chlorophenylpyrazolo<3,4-d>pyrimidine

Downstream raw materials:

1-p-Chlorophenyl-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one

1-(4-Chlorophenyl)-1,4,6,7,8,9-hexahydropyrazolo<3',4':4,5>pyrimido<2,1-c><1,2,4>triazin-7-one

8-Butyl-1-(4-chlorophenyl)-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one

8-Benzyl-1-(4-chlorophenyl)-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one