5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

Base Information

Chemical Name:5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one
CAS No.:170912-74-0
Molecular Formula:C₃₀H₃₉N₅O₆
Molecular Weight:565.67
Hs Code.:

Synonyms:5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

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Chemical Property of 5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

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Technology Process of 5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

There total 5 articles about 5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53157-48-5
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate

: 1027160-41-3
5-Chloro-1-[4-(4-nitro-phenyl)-piperazin-1-yl]-pentan-1-one

: 170912-74-0
5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Yield given;
DOI:10.1021/jm00018a020

Reference yield:

: 1575-61-7
5-Chlorovaleroyl chloride

: 170912-74-0
5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: CaCO₃ / butan-2-one / Ambient temperature

2: Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

With caesium carbonate; calcium carbonate; In N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00018a020

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 170912-74-0
5-[3-(2-{N-tert-Butoxycarbonyl}aminoethyl)-1H-indol-5-yloxy]-1-[4-(4-nitrophenyl)piperazin-1-yl]pentan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. NaOH / 1 h / Ambient temperature

2: Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

With sodium hydroxide; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00018a020