3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

Base Information

Chemical Name:3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride
CAS No.:1610671-14-1
Molecular Formula:C₂₃H₂₁ClN₄O₃
Molecular Weight:436.898
Hs Code.:

Synonyms:3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

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Chemical Property of 3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

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Technology Process of 3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

There total 5 articles about 3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610671-13-0
3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-14-1
3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

Guidance literature:: 3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate; With sodium hydroxide; In acetonitrile; at 20 ℃; for 12h;

With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1607830-93-2
methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-14-1
3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dipotassium hydrogenphosphate / tetrahydrofuran; water / 0.75 h / 150 °C / Microwave irradiation

2.1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.17 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

4.1: sodium hydroxide / acetonitrile / 12 h / 20 °C

4.2: 20 °C

With sodium tetrahydroborate; dipotassium hydrogenphosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; nickel dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;

Reference yield:

: 1610671-11-8
methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-14-1
3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.17 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

3.1: sodium hydroxide / acetonitrile / 12 h / 20 °C

3.2: 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; nickel dichloride; In ethanol; dichloromethane; acetonitrile;