3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

Base Information

Chemical Name:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid
CAS No.:852947-84-3
Molecular Formula:C₁₈H₂₀Cl₂NO₇PS
Molecular Weight:496.305
Hs Code.:

Synonyms:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

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Chemical Property of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

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Technology Process of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

There total 3 articles about 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 852947-90-1
diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

: 852947-84-3
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

Guidance literature:: diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 16.5h;

With water;

Reference yield:

: 35458-42-5
3,5-dichloro-4-(4-hydroxy-phenoxy)-benzoic acid

: 852947-84-3
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetyl chloride / methanol / 5 h / 0 °C / Heating / reflux

2.1: chlorosulfonic acid / chloroform / 1 h / 0 °C

3.1: tetrahydrofuran / 16 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

6.1: toluene / 8 h / 20 - 130 °C

7.1: trimethylsilyl bromide / dichloromethane / 16.5 h / 0 - 20 °C

With chlorosulfonic acid; trimethylsilyl bromide; phosphorus tribromide; diisobutylaluminium hydride; acetyl chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; toluene;

Reference yield:

: C₁₄H₁₀Cl₂O₇S

: 852947-84-3
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

4.1: toluene / 8 h / 20 - 130 °C

5.1: trimethylsilyl bromide / dichloromethane / 16.5 h / 0 - 20 °C

With trimethylsilyl bromide; phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; toluene;