diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

Base Information

Chemical Name:diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate
CAS No.:852947-90-1
Molecular Formula:C₂₂H₂₈Cl₂NO₇PS
Molecular Weight:552.413
Hs Code.:

Synonyms:diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

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Chemical Property of diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

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Technology Process of diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

There total 3 articles about diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 852947-89-8
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

: 122-52-1
triethyl phosphite

: 852947-90-1
diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

Guidance literature:: In toluene; at 20 - 130 ℃; for 8h;

Reference yield:

: 35458-42-5
3,5-dichloro-4-(4-hydroxy-phenoxy)-benzoic acid

: 852947-90-1
diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetyl chloride / methanol / 5 h / 0 °C / Heating / reflux

2.1: chlorosulfonic acid / chloroform / 1 h / 0 °C

3.1: tetrahydrofuran / 16 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

6.1: toluene / 8 h / 20 - 130 °C

With chlorosulfonic acid; phosphorus tribromide; diisobutylaluminium hydride; acetyl chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; toluene;

Reference yield:

: C₁₄H₁₀Cl₂O₇S

: 852947-90-1
diethyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

4.1: toluene / 8 h / 20 - 130 °C

With phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; toluene;