ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate
• CAS No.: 78942-23-1
• Molecular Formula: C₂₂H₁₉N₃O₂
• Molecular Weight: 357.412
• Mol file: 78942-23-1.mol

Synonyms:ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate

Chemical Property of ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate

There total 5 articles about ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl acetoacetate (141-97-9) + benzaldehyde (100-52-7) + aniline (62-53-3) + malononitrile (109-77-3) → ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate (78942-23-1)

Guidance literature:

With Cu⁽⁰⁾ on sulfonic acid functionalized silica/carbon composite derived from silica and cellulose; In neat (no solvent); at 100 ℃; for 2.5h; Solvent; Temperature; Catalytic behavior; Green chemistry;

DOI:10.1039/c6ra19840f

Reference yield: 70.0%

ethyl 6-chloro-5-cyano-2-methyl-4-phenylpyridine-3-carboxylate (78942-26-4) + aniline (62-53-3) → ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate (78942-23-1)

Guidance literature:

Reference yield:

nitrobenzene (98-95-3,26969-40-4) → ethyl 5-cyano-2-methyl-4-phenyl-6-(phenylamino)pyridine-3-carboxylate (78942-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; hydrogen / ethanol / 2 h / 20 °C

2: copper nanoparticles decorated on N-Doped carbon nanotubes / ethanol / 2 h / 80 °C

With hydrogen; acetic acid; In ethanol; 2: |Hantzsch Pyridine Synthesis;

DOI:10.1039/c6nj01464j

upstream raw materials:

ethyl 6-chloro-5-cyano-2-methyl-4-phenylpyridine-3-carboxylate

aniline

ethyl 2-benzylidene acetoacetate

5-cyano-2-methyl-6-oxo-4-phenyl-1,6?dihydropyridine-3-carboxylic acid ethyl ester