S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

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Chemical Name:S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate
CAS No.:203392-60-3
Molecular Formula:C₃₁H₄₄O₄S₂
Molecular Weight:544.82
Hs Code.:

Synonyms:S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

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Chemical Property of S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

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Technology Process of S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

There total 5 articles about S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 203392-58-9
S-tert-butyl (2R)-[(1R,2R)-3-oxo-2-(3-oxo-4-phenylthiobutyl)cyclopentyl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

: 203392-60-3
S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

Guidance literature:: With potassium hydroxide; In methanol;
DOI:10.1016/S0040-4039(97)10647-5

Reference yield:

: 203392-53-4
(S)-6-Hydroxy-7,7-dimethyl-oxepan-2-one

: 203392-60-3
S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AlMe₃; 2.) TsOH

2: 92 percent / lithium diisopropylamide / -78 deg C to RT

3: TrSbCl₆ / CH₂Cl₂ / -78 °C

4: CH₂Cl₂

5: 84 percent / KOH / methanol

With potassium hydroxide; trimethylaluminum; triphenylmethylium hexachloroantimonate(V); toluene-4-sulfonic acid; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10647-5

Reference yield:

: 203392-54-5
S-tert-butyl 4-[(3S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

: 203392-60-3
S-tert-butyl (2R)-2-[(1R,7aR)-7a-methyl-5-oxo-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / lithium diisopropylamide / -78 deg C to RT

2: TrSbCl₆ / CH₂Cl₂ / -78 °C

3: CH₂Cl₂

4: 84 percent / KOH / methanol

With potassium hydroxide; triphenylmethylium hexachloroantimonate(V); lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10647-5