4-AMINO-3-NITROBENZYLAMINE Hydrochloride

Base Information

• Chemical Name: 4-AMINO-3-NITROBENZYLAMINE Hydrochloride
• CAS No.: 79556-69-7
• Molecular Formula: C7H9 N3 O2
• Molecular Weight: 167.17
• Mol file: 79556-69-7.mol

Synonyms:4-Amino-3-nitrobenzylamine

Chemical Property of 4-AMINO-3-NITROBENZYLAMINE Hydrochloride

Chemical Property:

• PSA: 97.86000
• LogP: 2.44040

Purity/Quality:

99%min ^*data from raw suppliers

4-Amino-3-nitrobenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-3-NITROBENZYLAMINE Hydrochloride

There total 3 articles about 4-AMINO-3-NITROBENZYLAMINE Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol hydrochloride (101752-05-0) + 4-Amino 3-nitro-benzonitrile (6393-40-4) → 1-amino-2-nitro-4-aminomethylbenzene (79556-69-7)

Guidance literature:

With diborane; In tetrahydrofuran; methanol;

Reference yield:

4-Amino 3-nitro-benzonitrile (6393-40-4) → 1-amino-2-nitro-4-aminomethylbenzene (79556-69-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 10 ℃; for 2h;

DOI:10.1021/jm00107a035

Reference yield:

4-Cyanochlorobenzene (623-03-0) → 1-amino-2-nitro-4-aminomethylbenzene (79556-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / fuming HNO₃, conc. H₂SO₄ / 2 h / 10 - 15 °C

2: 63 percent / NH₃ / methanol / 72 h / Ambient temperature

3: BH₃*THF / tetrahydrofuran / 2 h / 10 °C

With borane-THF; sulfuric acid; ammonia; nitric acid; In tetrahydrofuran; methanol;

DOI:10.1021/jm00107a035

upstream raw materials:

4-Amino 3-nitro-benzonitrile

4-Cyanochlorobenzene

methanol hydrochloride

Downstream raw materials:

(4-Amino-3-nitro-benzyl)-carbamic acid tert-butyl ester

1-<<(tert-butoxycarbonyl)amino>methyl>-3,4-diaminobenzene

Refernces

• 1、 -. "Cephalosporin derivatives". . . Retrieved 2008/06/13.