(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid

Base Information

• Chemical Name: (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid
• CAS No.: 287210-82-6
• Molecular Formula: C₁₃H₂₅NO₄
• Molecular Weight: 259.346

Synonyms:(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid

Chemical Property of (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

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Technology Process of (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid

There total 1 articles about (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(tert-butoxycarbonyl)-L-tert-leucine (112695-98-4,79777-82-5) + methyl iodide (74-88-4) → (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid (287210-82-6,287210-83-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 35 ℃;

Reference yield: 100.0%

(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid (287210-82-6,287210-83-7) + benzyl (S)-Lactate (56777-24-3) → (2R)-1-(benzyloxy)-1-oxopropan-2-yl (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4,4-dimethylpentanoate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Reagent/catalyst;

Reference yield: 95.0%

(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid (287210-82-6,287210-83-7) + (R)-benzyl mandelate (7622-21-1,93434-59-4,7622-22-2) → (2R)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-yl (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4,4-dimethylpentanoate

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

N-(tert-butoxycarbonyl)-L-tert-leucine

methyl iodide

Downstream raw materials:

tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate

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