ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

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Chemical Name:ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate
CAS No.:1422503-25-0
Molecular Formula:C₃₇H₄₂N₂O₆S
Molecular Weight:642.816
Hs Code.:

Synonyms:ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

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Chemical Property of ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

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Technology Process of ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

There total 4 articles about ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114347-51-1
ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate

: 51608-60-7
N-(benzylidene)-p-methylbenzenesulfonamide

: 1422503-25-0
ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

Guidance literature:: ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N-(benzylidene)-p-methylbenzenesulfonamide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1021/jo302018a

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 1422503-25-0
ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 1.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo302018a

Reference yield:

: 28709-71-9
ethyl (S)-2-(N-benzylamino)-3-phenylpropanoate

: 1422503-25-0
ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo302018a