ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate
• CAS No.: 1114347-51-1
• Molecular Formula: C₂₃H₂₉NO₄
• Molecular Weight: 383.488
• Mol file: 1114347-51-1.mol

Synonyms:ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate

Chemical Property of ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate

There total 3 articles about ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl (S)-2-(N-benzylamino)-3-phenylpropanoate (28709-71-9) → ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate (1114347-51-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.11.050

Reference yield:

(L)-phenylalanine ethyl ester hydrochloride (3182-93-2) → ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate (1114347-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 1.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo302018a

Reference yield:

benzaldehyde (100-52-7) → ethyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-phenylpropanoate (1114347-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 1.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo302018a

upstream raw materials:

di-tert-butyl dicarbonate

ethyl (S)-2-(N-benzylamino)-3-phenylpropanoate

(L)-phenylalanine ethyl ester hydrochloride

benzaldehyde

Downstream raw materials:

ethyl 2-benzyl-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]-3-(4-methylphenylsulfonamido)-3-phenylpropanoate