tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1428327-33-6
Molecular Formula:C₃₂H₄₄N₄O₃
Molecular Weight:532.726
Hs Code.:

Synonyms:tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 5 articles about tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 872001-50-8
2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid

: 891374-38-2
(1-(4-phenylpiperazin-1-yl)cyclohexyl)methanamine

: 1428327-33-6
tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ml400040v

Reference yield:

: 1428327-32-5
2-tert-butyl 5-methyl 3,4-dihydroisoquinoline-2,5(1H)-dicarboxylate

: 1428327-33-6
tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

2: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 8 h / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In methanol; water;
DOI:10.1021/ml400040v

Reference yield:

: 39230-30-3
1-Cyano-1-(4-phenylpiperazin-1-yl)-cyclohexane

: 1428327-33-6
tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 8 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ml400040v