Technology Process of (2Z)-1,2,3,6-tetrahydro-4-methyl-3-methylene-2-((trimethylsilyl)methylene)-1-(p-tosyl)pyridine
There total 6 articles about (2Z)-1,2,3,6-tetrahydro-4-methyl-3-methylene-2-((trimethylsilyl)methylene)-1-(p-tosyl)pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silver trifluoromethanesulfonate;
In
dichloromethane;
at 25 ℃;
for 0.17h;
Inert atmosphere;
DOI:10.1021/ol201041h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: iron(III) chloride hexahydrate; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 16 h / 90 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 - 25 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
4.1: copper(l) iodide; lithium bromide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
4.2: -78 - 25 °C / Inert atmosphere
5.1: silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 25 °C / Inert atmosphere
With
copper(l) iodide; n-butyllithium; iron(III) chloride hexahydrate; silver trifluoromethanesulfonate; potassium carbonate; triethylamine; lithium bromide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol201041h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 25 °C / Inert atmosphere
2.1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.1: copper(l) iodide; lithium bromide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
3.2: -78 - 25 °C / Inert atmosphere
4.1: silver trifluoromethanesulfonate / dichloromethane / 0.17 h / 25 °C / Inert atmosphere
With
copper(l) iodide; n-butyllithium; silver trifluoromethanesulfonate; triethylamine; lithium bromide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol201041h
