(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Chemical Name:(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid
CAS No.:1430216-64-0
Molecular Formula:C₂₆H₂₃ClN₈O₄
Molecular Weight:546.973
Hs Code.:

Synonyms:(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Chemical Property of (E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Technology Process of (E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

There total 9 articles about (E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430217-80-3
3-acetyl-1-benzyl-4-hydroxy-5,6-dihydropyridin-2(1H)-one

: 1430216-73-1
(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-2,3-dimethyl-4,5,6,7-tetrahydro-2H-pyrazolo(4,3-c)pyridine-4-carboxamido)benzoic acid

: 1430216-64-0
(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: 3-acetyl-1-benzyl-4-hydroxy-5,6-dihydropyridin-2(1H)-one; With potassium carbonate; In ethanol; for 18h; Reflux;

With lithium aluminium tetrahydride; at 0 - 70 ℃; for 18h; Overall yield = 20 mg; Further stages;

Reference yield:

: 1430217-79-0
methyl 3-(N-benzyl-3-oxobutanamido)propanoate

: 1430216-64-0
(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 2 h / 0 - 50 °C

2.1: potassium carbonate / ethanol / 18 h / Reflux

2.2: 18 h / 70 °C

3.1: methanol / 72 h / 55 °C / Sealed tube

4.1: hydrogenchloride / dichloromethane / 1 h

With hydrogenchloride; sodium methylate; potassium carbonate; In methanol; ethanol; dichloromethane; 3.1: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: 879016-22-5
5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde

: 1430216-64-0
(E)-4-(5-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C

1.2: 0.5 h

2.1: sodium hydroxide / methanol / 2.5 h / 20 °C

3.1: methanol / 72 h / 55 °C / Sealed tube

4.1: hydrogenchloride / dichloromethane / 1 h

With hydrogenchloride; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 3.1: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171