3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Base Information

• Chemical Name: 3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone
• CAS No.: 934698-38-1
• Molecular Formula: C₂₀H₂₀ClNO
• Molecular Weight: 325.838

Synonyms:3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Chemical Property of 3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Chemical Property:

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Technology Process of 3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

There total 1 articles about 3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone (120343-66-0) + 4-chlorobenzaldehyde (104-88-1) → 3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (934698-38-1)

Guidance literature:

With pyrrolidine; for 0.05h; microwave irradiation;

DOI:10.1016/j.tetasy.2007.01.015

Reference yield: 55.0%

3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (934698-38-1) + (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride (74903-80-3) → (4R,5S)-3,4-bis(4-chlorophenyl)-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]dec-2-en-10-one + (4S,5R)-3,4-bis(4-chlorophenyl)-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]dec-2-en-10-one

Guidance literature:

With triethylamine; In benzene; at 20 ℃;

DOI:10.1016/j.tetasy.2007.01.015

Reference yield: 54.0%

3-[(E)-(4-chlorophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (934698-38-1) + phenylhydroxamoyl chloride (934-16-7) → (4R,5S)-4-(4-chlorophenyl)-3-phenyl-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]dec-2-en-10-one + (4S,5R)-4-(4-chlorophenyl)-3-phenyl-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]dec-2-en-10-one

Guidance literature:

With triethylamine; In benzene; at 20 ℃;

DOI:10.1016/j.tetasy.2007.01.015

upstream raw materials:

(R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone

4-chlorobenzaldehyde

Downstream raw materials:

(3R,4R,5S)-4-(4-chlorophenyl)-3-(4-methylphenyl)-2-phenyl-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]decan-10-one

(3S,4S,5R)-4-(4-chlorophenyl)-3-(4-methylphenyl)-2-phenyl-7-[(R)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]decan-10-one

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