7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

Base Information

Chemical Name:7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate
CAS No.:1407815-02-4
Molecular Formula:C₂H₄O₂*C₁₄H₁₂FN₅
Molecular Weight:329.334
Hs Code.:

Synonyms:7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

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Chemical Property of 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

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Technology Process of 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

There total 9 articles about 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1407814-98-5
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile

: 64-19-7,77671-22-8
acetic acid

: 1407815-02-4
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

Guidance literature:: 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile; With sodium methylate; In methanol; at 20 ℃; for 16h;

acetic acid; With ammonium chloride; for 8h; Reflux;

Reference yield: 71.0%

: 1407814-98-5
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile

: 1407815-02-4
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

Guidance literature:: With ammonium chloride; sodium methylate; acetic acid; In methanol; water;

Reference yield:

: 1407814-85-0
2-(2-fluorophenyl)-N-[(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)methyl]acetamide

: 1407815-02-4
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / acetic acid / 3 h / 50 °C

2.1: trichlorophosphate / sulfolane / 3 h / 100 °C

3.1: 5%-palladium/activated carbon; hydrogen; triethylamine / ethyl acetate / 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 0.17 h / 20 °C

5.1: dimethyl sulfoxide / 3.5 h / 170 °C

6.1: sodium methylate / methanol / 16 h / 20 °C

6.2: 8 h / Reflux

With N-Bromosuccinimide; 5%-palladium/activated carbon; hydrogen; bromine; sodium methylate; triethylamine; trichlorophosphate; In sulfolane; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; ethyl acetate;