2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

Base Information

Chemical Name:2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine
CAS No.:1407978-23-7
Molecular Formula:C₂₃H₁₈FN₉
Molecular Weight:439.455
Hs Code.:

Synonyms:2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

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Chemical Property of 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

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Technology Process of 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

There total 2 articles about 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-2-(phenyldiazenyl)malononitrile

: 1407815-02-4
7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate

: 1407978-23-7
2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 22h;

Reference yield:

: 62-53-3
aniline

: 1407978-23-7
2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 2 h / 0 °C

2.1: triethylamine / N,N-dimethyl-formamide / 22 h / 100 °C

With hydrogenchloride; triethylamine; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

: 1407978-23-7
2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

: 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidine-4,5,6-triamine trihydrochloride

Guidance literature:: 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine; With palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide; for 18h;

With hydrogenchloride; In water;