8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Base Information

Chemical Name:8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine
CAS No.:321906-95-0
Molecular Formula:C₃₁H₄₇FN₄O₅SSi
Molecular Weight:634.888
Hs Code.:

Synonyms:8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

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Chemical Property of 8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

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Technology Process of 8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

There total 7 articles about 8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 321906-89-2
5-(4-fluorosulfonylphenyl)pentyl bromide

: 321906-97-2
8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

: 321906-95-0
8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Guidance literature:: 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine; With potassium carbonate; In N,N-dimethyl-formamide; for 1h;

5-(4-fluorosulfonylphenyl)pentyl bromide; In N,N-dimethyl-formamide;
DOI:10.1021/jm000181f

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 321906-95-0
8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 97 percent / dimethylformamide

2.1: 89 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h

3.1: K₂CO₃ / dimethylformamide / 1 h

3.2: 45 percent / dimethylformamide

With ammonium formate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000181f

Reference yield:

: 3-benzyl-8-cyclohexyl-1-propyl-3,7-dihydro-purine-2,6-dione

: 321906-95-0
8-cyclohexyl-3-(5-(4-fluorosulfonylphenyl)pentyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 97 percent / dimethylformamide

2.1: 89 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h

3.1: K₂CO₃ / dimethylformamide / 1 h

3.2: 45 percent / dimethylformamide

With ammonium formate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000181f