a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride

Base Information

• Chemical Name: a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride
• CAS No.: 1449650-87-6
• Molecular Formula: C₁₉H₂₄N₂*ClH
• Molecular Weight: 316.874

Synonyms:a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride

Chemical Property of a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride

Chemical Property:

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Technology Process of a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride

There total 2 articles about a-methylamino-3-phenyl-1-tricyclo [3.3.1.1^3,7]decaneacetonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium cyanide (773837-37-9) + 3-phenyl-1-tricyclo[3.3.1.13,7]decanecarboxaldehyde (29835-32-3) + methylamine hydrochloride (593-51-1) → a-methylamino-3-phenyl-1-tricyclo [3.3.1.13,7]decaneacetonitrile hydrochloride (1449650-87-6)

Guidance literature:

In water; dimethyl sulfoxide; at 20 - 60 ℃; for 55h; Inert atmosphere;

DOI:10.1039/c3md00081h

Reference yield:

3-phenyl-adamantane-1-carboxylic acid (37589-22-3) → a-methylamino-3-phenyl-1-tricyclo [3.3.1.13,7]decaneacetonitrile hydrochloride (1449650-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2: dimethyl sulfoxide; water / 55 h / 20 - 60 °C / Inert atmosphere

With pyridinium chlorochromate; In dichloromethane; water; dimethyl sulfoxide; 2: |Strecker Aminoacid Synthesis;

DOI:10.1039/c3md00081h

Reference yield: 100.0%

a-methylamino-3-phenyl-1-tricyclo [3.3.1.13,7]decaneacetonitrile hydrochloride (1449650-87-6) → 1-(3-cyclohexyl-1-tricyclo[3.3.1.13,7] decyl)-N1-methyl-1,2-ethanediamine dihydrochloride

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; ethanol; at 60 ℃; for 8h; under 2844.39 Torr;

DOI:10.1039/c3md00081h

upstream raw materials:

3-phenyl-adamantane-1-carboxylic acid

sodium cyanide

3-phenyl-1-tricyclo[3.3.1.1^3,7]decanecarboxaldehyde

methylamine hydrochloride

Downstream raw materials:

5-(3-cyclohexyl-1-tricyclo[3.3.1.1^3,7]decyl)-4.5-dihydro-1-methyl-1H-2-imidazolamine hydrobromide

4,5-dihydro-1-methyl-5-(3-phenyl-1-tricyclo[3.3.1.1^3,7]decyl)-1H-imidazoline

4,5-dihydro-1-methyl-5-(3-phenyl-1-tricyclo[3.3.1.1^3,7]decyl)-1H-imidazoline hydrochloride

4,5-dihydro-1,2-dimethyl-5-(3-phenyl-1-tricyclo[3.3.1.1^3,7]decyl)-1H-imidazole

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