Ethyl 5,5,5-trifluoropent-2-enoate

Base Information

Chemical Name:Ethyl 5,5,5-trifluoropent-2-enoate
CAS No.:137131-12-5
Molecular Formula:C₇H₉F₃O₂
Molecular Weight:182.142
Hs Code.:2916199590
European Community (EC) Number:802-208-4

Synonyms:Ethyl 5,5,5-trifluoropent-2-enoate;137131-12-5;ethyl (E)-5,5,5-trifluoropent-2-enoate;1802225-80-4;MFCD18641871;ethyl 4-triflouromethylcrotonate;SCHEMBL5643847;SCHEMBL8152585;Ethyl 5,5,5-trifluoro-2-pentenoate;AKOS006371286;ethyl (2E)-5,5,5-trifluoropent-2-enoate;G30576;EN300-4687764;(E)-5,5,5-Trifluoro-pent-2-enoic acid ethyl ester

Suppliers and Price of Ethyl 5,5,5-trifluoropent-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl5,5,5-Trifluoropent-2-enoate
2.5g
$ 960.00

SynQuest Laboratories
Ethyl 5,5,5-trifluoro-2-pentenoate
50 g
$ 1068.00

Total 1 raw suppliers

Chemical Property of Ethyl 5,5,5-trifluoropent-2-enoate

Chemical Property:

Boiling Point:137.4±40.0 °C(Predicted)
Density:1.155±0.06 g/cm3(Predicted)
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:182.05546401
Heavy Atom Count:12
Complexity:172

Purity/Quality:: Ethyl5,5,5-Trifluoropent-2-enoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C=CCC(F)(F)F
Isomeric SMILES:CCOC(=O)/C=C/CC(F)(F)F
Uses Ethyl 5,5,5-trifluoropent-2-enoate is a reagent in the synthesis of EFGR inhibitors which may be used in cancer patients with oncogenic mutations. Also used in the preparation of potent nicotinic acetylcholine receptor agonists.

Technology Process of Ethyl 5,5,5-trifluoropent-2-enoate

There total 2 articles about Ethyl 5,5,5-trifluoropent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 37746-78-4
4-bromo-trans-crotonic acid ethyl ester

: 97571-11-4
(trifluoromethyl)cadmiumbromide

: 137131-12-5
ethyl (2E)-5,5,5-trifluoropent-2-enoate

Guidance literature:: With copper(l) iodide; In N,N-dimethyl-formamide; -78 deg C -> RT;

Reference yield: 37.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 460-40-2
3,3,3-trifluoropropanal

: 137131-12-5
ethyl (2E)-5,5,5-trifluoropent-2-enoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

3,3,3-trifluoropropanal; In tetrahydrofuran; mineral oil; at -70 - -20 ℃; for 2h;