3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI)

Base Information

• Chemical Name: 3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI)
• CAS No.: 790657-32-8
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.197
• Mol file: 790657-32-8.mol

Synonyms:3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI)

Chemical Property of 3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI)

There total 4 articles about 3-Cyclopentene-1-carboxylicacid,2-amino-,ethylester,(1R,2S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethanol (64-17-5) + (1S,5R)-6-azabicyclo[3.2.0]hept-3-en-7-one (146864-12-2) → C8H13NO2 (1006611-38-6,790657-32-8,771440-02-9)

Guidance literature:

With hydrogenchloride; at 0 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.11.043

Reference yield:

ethanol (64-17-5) + (+)-(1R,2S)-2-aminocyclopent-3-ene-1-carboxylic acid (138039-48-2,154568-20-4,122022-98-4) → C8H13NO2 (790657-32-8,771440-02-9)

Guidance literature:

With thionyl chloride; at 70 ℃; for 3h;

DOI:10.1016/j.tet.2011.04.005

Reference yield:

6-Azabicyclo<3.2.0>hept-3-en-7-one (63838-48-2,97911-48-3,138127-85-2,146864-12-2) → C8H13NO2 (790657-32-8,771440-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Candida antarctica lipase B; water / tert-butyl methyl ether / 4.5 h / 80 °C / Resolution of racemate; Enzymatic reaction

2: thionyl chloride

With Candida antarctica lipase B; thionyl chloride; water; In tert-butyl methyl ether;

DOI:10.1002/ejoc.201301281

upstream raw materials:

ethanol

(+)-(1R,2S)-2-aminocyclopent-3-ene-1-carboxylic acid

6-Azabicyclo<3.2.0>hept-3-en-7-one

(1S,5R)-6-azabicyclo[3.2.0]hept-3-en-7-one