(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Base Information

Chemical Name:(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol
CAS No.:168749-05-1
Molecular Formula:C₂₂H₂₇BrN₂O
Molecular Weight:415.373
Hs Code.:

Synonyms:(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Suppliers and Price of (+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

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Technology Process of (+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

There total 5 articles about (+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 500912-24-3
(2R,5S)-1-Allyl-4-{(3-bromo-phenyl)-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl}-2,5-dimethyl-piperazine

: 168749-05-1
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

: 155836-82-1
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: With tetraethylammonium fluoride; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jm020395s

Reference yield:

: 591-20-8
3-Bromophenol

: 168749-05-1
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / dimethylformamide / 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

3.1: thionyl chloride / CH₂Cl₂ / 20 °C

4.1: acetonitrile / 48 h / Heating

5.1: tetraethylammonium fluoride dihydrate / acetonitrile / 1 h / 20 °C

With 1H-imidazole; n-butyllithium; thionyl chloride; tetraethylammonium fluoride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm020395s

Reference yield:

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 168749-05-1
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 °C

2.1: thionyl chloride / CH₂Cl₂ / 20 °C

3.1: acetonitrile / 48 h / Heating

4.1: tetraethylammonium fluoride dihydrate / acetonitrile / 1 h / 20 °C

With n-butyllithium; thionyl chloride; tetraethylammonium fluoride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jm020395s