Phenol, 3-[(S)-(3-bromophenyl)[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazin yl]methyl]-

Base Information

Chemical Name:Phenol, 3-[(S)-(3-bromophenyl)[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazin yl]methyl]-
CAS No.:155836-82-1
Molecular Formula:C22H27BrN2O
Molecular Weight:415.373
Hs Code.:
Mol file:155836-82-1.mol

Synonyms:

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Chemical Property of Phenol, 3-[(S)-(3-bromophenyl)[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazin yl]methyl]-

Chemical Property:

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Technology Process of Phenol, 3-[(S)-(3-bromophenyl)[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazin yl]methyl]-

There total 6 articles about Phenol, 3-[(S)-(3-bromophenyl)[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazin yl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 500912-24-3
(2R,5S)-1-Allyl-4-{(3-bromo-phenyl)-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl}-2,5-dimethyl-piperazine

: 168749-05-1
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

: 155836-82-1
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: With tetraethylammonium fluoride; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jm020395s

Reference yield:

: 591-20-8
3-Bromophenol

: 155836-82-1
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / dimethylformamide / 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

3.1: thionyl chloride / CH₂Cl₂ / 20 °C

4.1: acetonitrile / 48 h / Heating

5.1: tetraethylammonium fluoride dihydrate / acetonitrile / 1 h / 20 °C

With 1H-imidazole; n-butyllithium; thionyl chloride; tetraethylammonium fluoride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm020395s

Reference yield:

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 155836-82-1
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-bromobenzyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 °C

2.1: thionyl chloride / CH₂Cl₂ / 20 °C

3.1: acetonitrile / 48 h / Heating

4.1: tetraethylammonium fluoride dihydrate / acetonitrile / 1 h / 20 °C

With n-butyllithium; thionyl chloride; tetraethylammonium fluoride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jm020395s