(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

Base Information

Chemical Name:(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid
CAS No.:1578153-81-7
Molecular Formula:C₂₂H₂₂ClFN₄O₅S
Molecular Weight:508.958
Hs Code.:

Synonyms:(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

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Chemical Property of (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

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Technology Process of (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

There total 16 articles about (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

: 106825-79-0,106825-81-4
(S)-morpholine-3-carboxylic acid

: 1578153-81-7
(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

Guidance literature:: With potassium carbonate; In ethanol; at 30 ℃; for 12h; Inert atmosphere;

Reference yield: 69.0%

: 64-17-5
ethanol

: (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-((((S)-1-isopropoxy-1-oxopropan-2-yl)oxy)carbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

: 1578153-81-7
(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

Guidance literature:: ethanol; With lithium; at 43 ℃;

(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-((((S)-1-isopropoxy-1-oxopropan-2-yl)oxy)carbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid; at 78 ℃; for 6h;

Reference yield: 65.0%

: 64-17-5
ethanol

: (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-((((R)-1-ethoxy-1-oxopropan-2-yl)oxy)carbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

: 1578153-81-7
(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-?4-yl)methyl)morpholine-3-carboxylic acid

Guidance literature:: ethanol; With lithium; at 43 ℃;

(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-((((R)-1-ethoxy-1-oxopropan-2-yl)oxy)carbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid; at 78 ℃; for 12h;