N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

Base Information

Chemical Name:N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide
CAS No.:1429294-61-0
Molecular Formula:C₂₆H₂₅ClN₆O₃
Molecular Weight:504.976
Hs Code.:

Synonyms:N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

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Chemical Property of N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

Chemical Property:

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Technology Process of N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

There total 9 articles about N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266584-24-0
N¹-(2-(2-amino-4-chlorophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine

: 122-04-3
4-nitro-benzoyl chloride

: 1429294-61-0
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 41995-04-4
4-chloro-2-nitro-benzoyl chloride

: 1429294-61-0
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / chloroform / 5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

4: tetrahydrofuran / 5 h / Reflux

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 5 h / 0 - 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 1429294-61-0
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 1.5 h / 80 °C

2: triethylamine / chloroform / 5 h / 20 °C

3: potassium hydroxide / ethanol / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

5: tetrahydrofuran / 5 h / Reflux

6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

7: dichloromethane / 5 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051