Technology Process of (R)-[7-(benzyloxy)hept-1-en-3-yloxy](tert-butyl)diphenylsilane
There total 6 articles about (R)-[7-(benzyloxy)hept-1-en-3-yloxy](tert-butyl)diphenylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C
1.2: 4 h / 0 - 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
2.2: 0.5 h / 0 °C
3.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
4.2: 5 h / -20 °C / Molecular sieve
5.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C
With
1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; diethyl (2R,3R)-tartrate; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1002/ejoc.201101601
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
1.2: 0.5 h / 0 °C
2.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
3.2: 5 h / -20 °C / Molecular sieve
4.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C
With
1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; diethyl (2R,3R)-tartrate; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1002/ejoc.201101601
