N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide

Base Information

• Chemical Name: N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide
• CAS No.: 948995-63-9
• Molecular Formula: C₂₃H₂₇N₅O₆
• Molecular Weight: 469.497
• Mol file: 948995-63-9.mol

Synonyms:N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide

Chemical Property of N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide

There total 9 articles about N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C24H30N2O9S → N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide (948995-63-9)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jo070621b

Reference yield:

4-[3,5-dimethyl-4-(4-nitro-benzyloxy)-phenyl]-4-oxo-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester (948995-62-8) → N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide (948995-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: pyridine / 12 h / 20 °C

3: 70 percent / NaN₃ / dimethylformamide / 12 h / 20 °C

With pyridine; sodium azide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo070621b

Reference yield:

C19H19NO6 (1012794-99-8) → N-[2-(2-azidoethoxy)ethyl]-4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyramide (948995-63-9)

Guidance literature:

Multi-step reaction with 4 steps

1: EDAC / CH₂Cl₂ / 3 h / 20 °C

2: CH₂Cl₂ / 3 h / 20 °C

3: pyridine / 12 h / 20 °C

4: 70 percent / NaN₃ / dimethylformamide / 12 h / 20 °C

With pyridine; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo070621b

upstream raw materials:

4-[3,5-dimethyl-4-(4-nitro-benzyloxy)-phenyl]-4-oxo-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

C₁₉H₁₉NO₆

4-(4-methoxy-3,5-dimethylphenyl)-4-oxobutyric acid methyl ester

4-[3,5-dimethyl-4-(4-nitro-benzyloxy)-phenyl]-4-oxo-butyric acid methyl ester

Downstream raw materials:

C₄₀H₄₉N₅O₁₆

C₅₂H₆₅N₅O₂₄

Refernces