1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

Base Information

Chemical Name:1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea
CAS No.:1299488-41-7
Molecular Formula:C₂₆H₃₁F₆N₃O₅S
Molecular Weight:611.606
Hs Code.:

Synonyms:1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

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Chemical Property of 1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

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Technology Process of 1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

There total 7 articles about 1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299488-45-1
2-(4-((4-(4-aminophenylsulfonyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 7693-46-1
4-Nitrophenyl chloroformate

: 1299488-41-7
1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: 2-(4-((4-(4-aminophenylsulfonyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol; 4-Nitrophenyl chloroformate; In tetrahydrofuran; at 20 ℃; for 0.5h;

1-Amino-2-methyl-propan-2-ol; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1849-36-1
para-nitrobenzenethiol

: 1299488-41-7
1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 60 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2250.23 Torr

5.1: potassium carbonate; dimethyl sulfoxide / acetonitrile / 1.5 h / 20 °C

6.1: tetrahydrofuran / 0.5 h / 20 °C

6.2: 20 °C

With hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 333986-94-0
4-(4-nitrophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

: 1299488-41-7
1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylsulfonyl)phenyl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2250.23 Torr

4.1: potassium carbonate; dimethyl sulfoxide / acetonitrile / 1.5 h / 20 °C

5.1: tetrahydrofuran / 0.5 h / 20 °C

5.2: 20 °C

With hydrogen; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;