α-Methyl-stilben-2-carbonsaeure

Base Information

• Chemical Name: α-Methyl-stilben-2-carbonsaeure
• CAS No.: 93022-29-8
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 93022-29-8.mol

Synonyms:α-Methyl-stilben-2-carbonsaeure

Chemical Property of α-Methyl-stilben-2-carbonsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Methyl-stilben-2-carbonsaeure

There total 8 articles about α-Methyl-stilben-2-carbonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

1-Phenylprop-1-yne (673-32-5) + benzoic acid (65-85-0,8013-63-6) → 1,1-diphenyl-1-propene (778-66-5) + (E)-1,2-diphenylpropene (833-81-8) + α-Methyl-stilben-2-carbonsaeure (93022-29-8) + C24H22

Guidance literature:

With [RuCl₂(hexamethylbenzene)]2; mesitylenecarboxylic acid; diguanidine carbonate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00300

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + (Z)-(1-bromoprop-1-ene-1,2-diyl)dibenzene (63904-73-4) → (E)-2-(1-phenylprop-1-en-2-yl)benzoic acid (93022-29-8) + 2-<(Z)-1-methyl-2-phenylethenyl>benzoic acid

Guidance literature:

With C₂₄H₁₈Br₂F₆N₄Ni; In N,N-dimethyl acetamide; at 15 ℃; for 12h; under 760.051 Torr; Overall yield = 65 percent; Overall yield = 46.8 mg; Schlenk technique;

DOI:10.1021/jacs.0c08810

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + (E)-(1-bromoprop-1-ene-1,2-diyl)dibenzene (63904-72-3) → (E)-2-(1-phenylprop-1-en-2-yl)benzoic acid (93022-29-8) + 2-<(Z)-1-methyl-2-phenylethenyl>benzoic acid

Guidance literature:

With C₂₄H₁₈Br₂F₆N₄Ni; In N,N-dimethyl acetamide; at 15 ℃; for 12h; under 760.051 Torr; Overall yield = 44 percent; Overall yield = 31.4 mg; Schlenk technique;

DOI:10.1021/jacs.0c08810

upstream raw materials:

1-Phenylprop-1-yne

benzoic acid

3-benzyl-3-methylisobenzofuran-1(3H)-one

(RS)-3-((SR)-α-chloro-benzyl)-3-methyl-phthalide

Downstream raw materials:

2-((1RS,2RS)-2-hydroxy-1-methyl-2-phenyl-ethyl)-benzoic acid-lactone

3-benzoyl-3-methyl-phthalide