2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Base Information

• Chemical Name: 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide
• CAS No.: 220193-67-9
• Molecular Formula: C₃₉H₅₁N₅O₆
• Molecular Weight: 685.864

Synonyms:2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Chemical Property of 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Chemical Property:

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Technology Process of 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide

There total 4 articles about 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N¹-(3-naphthalen-1-yl-propyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-amino-N1-[3-(1-naphthalenyl)propyl]butanediamide (220193-52-2) → 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N1-(3-naphthalen-1-yl-propyl)-succinamide (220193-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

2: piperidine / acetonitrile / 1 h / Ambient temperature

3: acetonitrile / Ambient temperature

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In acetonitrile;

DOI:10.1021/jm980388x

Reference yield:

{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester (220193-51-1) → 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N1-(3-naphthalen-1-yl-propyl)-succinamide (220193-67-9)

Guidance literature:

Multi-step reaction with 4 steps

1: TFA, triethylsilane / 1 h / Ambient temperature

2: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

3: piperidine / acetonitrile / 1 h / Ambient temperature

4: acetonitrile / Ambient temperature

With piperidine; triethylsilane; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/jm980388x

Reference yield:

(2-(4-tert-butoxy-phenyl)-1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (220193-58-8) → 2-({1-[2-acetylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-cyclohexanecarbonyl}-amino)-N1-(3-naphthalen-1-yl-propyl)-succinamide (220193-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / acetonitrile / 1 h / Ambient temperature

2: acetonitrile / Ambient temperature

With piperidine; In acetonitrile;

DOI:10.1021/jm980388x

upstream raw materials:

N-Acetylimidazole

(2S)-2-amino-N₁-[3-(1-naphthalenyl)propyl]butanediamide

{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester

(2-(4-tert-butoxy-phenyl)-1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

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