3-phenylbicyclo<1.1.1>pentanecarbonitrile

Base Information

• Chemical Name: 3-phenylbicyclo<1.1.1>pentanecarbonitrile
• CAS No.: 83249-01-8
• Molecular Formula: C₁₂H₁₁N
• Molecular Weight: 169.226
• Mol file: 83249-01-8.mol

Synonyms:3-phenylbicyclo<1.1.1>pentanecarbonitrile

Chemical Property of 3-phenylbicyclo<1.1.1>pentanecarbonitrile

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenylbicyclo<1.1.1>pentanecarbonitrile

There total 2 articles about 3-phenylbicyclo<1.1.1>pentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-phenyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carbonitrile (65862-00-2) → 3-phenylbicyclo<1.1.1>pentanecarbonitrile (83249-01-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; at 130 ℃; for 35h;

DOI:10.1021/jo00146a031

Reference yield:

3-phenylbicyclo<1.1.0>butanecarbonitrile (30494-27-0) → 3-phenylbicyclo<1.1.1>pentanecarbonitrile (83249-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.23 g / bis-(2-methoxy-ethyl) ether; tetrachloroethene / 4 h / 100 °C

2: 68 percent / tri-n-butyltin hydride, azobis(isobutyronitrile) / 35 h / 130 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,1,2,2-tetrachloroethylene; diethylene glycol dimethyl ether;

DOI:10.1021/jo00146a031

Reference yield: 56.5%

3-phenylbicyclo<1.1.1>pentanecarbonitrile (83249-01-8) → 3-cyanobicyclo<1.1.1>pentane-1-carboxylic acid (83249-02-9)

Guidance literature:

With ruthenium(IV) oxide; sodium hydroxide; sodium hypochlorite; In tetrachloromethane; for 93h;

DOI:10.1021/jo00146a031

upstream raw materials:

3-phenyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carbonitrile

3-phenylbicyclo<1.1.0>butanecarbonitrile

Downstream raw materials:

3-cyanobicyclo<1.1.1>pentane-1-carboxylic acid